4-Benzyloxy-3-Nitro-Alpha-Bromoacetophenone

Applications

4-Benzyloxy-3-Nitro-Alpha-Bromoacetophenone is primarily used as a key pharmaceutical intermediate in the synthesis of specific active pharmaceutical ingredients (APIs), particularly those with a complex chemical structure derived from its core. Key applications include

1. Intermediate for Dronedarone Synthesis

Its most significant application is as a crucial building block in the multi-step synthesis of Dronedarone (marketed as Multaq). Dronedarone is an antiarrhythmic drug used to maintain normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation (AF) or atrial flutter (AFL).1 The compound's specific structure, with the benzyloxy, nitro, and bromoacetophenone functionalities, is essential for constructing the unique chemical scaffold of Dronedarone.

2. Organic Synthesis Research

Due to its specific functional groups (nitro, benzyloxy, and α-bromo ketone), it is a valuable reagent in organic synthesis for creating more complex molecules. The bromine atom is highly reactive, making it suitable for various coupling reactions or nucleophilic substitutions.

3. Fine Chemical

It is available as a specialized fine chemical for research and development purposes, particularly in medicinal chemistry for drug discovery and process development related to Dronedarone and its analogs.

Product Information

CAS Number

66935-18-0

Social Links

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4-Benzyloxy-3-Nitro-Alpha-Bromoacetophenone